Further studies that focus on bladder cancer have revealed that the dCas9 tethering with the CRY2-CIB1 (Cryptochrome 2-Calcium and Integrin Binding 1) photosensitive module can activate the expression of p53 and E-cadherin proteins, inhibiting the biological function of T24 tumor cells [126,127]. The gene discussed is CIB1; the disease is urinary bladder carcinoma.