The kallikrein-bradykinin system was upregulated in the LV of rats after OM infusion, with the increased myocardial LV expression of genes encoding the serine proteases Klk8, Klk1c2, and Klk1c12 (Figure 3D), as well as the bradykinin receptors (Bdkr) B1 and B2 (Figure 3E), which are G-protein-coupled receptors mediating kinin actions. The gene discussed is KNG1; the disease is ocular melanoma.