The present results show that a single 30-min infusion of myosin activator OM induced significant LV expression alterations in genes regulating apoptosis (with decreased pro-apoptotic Bax-to-Bcl2 ratio), oxidative stress (with increased antioxidant Gpx), cardiac metabolism (with decreased Glut1 and increased Lox1, Alox15, and Pdk4), and contraction (with increased AT1 and AT2, upregulation of kallikrein-bradykinin system, but no changes in molecules involved in Ca2+-dependent myocardial contraction) 7 weeks after OM infusion. The gene discussed is PDK4; the disease is ocular melanoma.