Unsurprisingly, the 57 single nucleotide polymorphisms (SNPs) including well-established SNPs in CDKN2B-AS1, TMCO1, CAV1/CAV2, chromosome 8q22 intergenic region, and SIX1/SIX6 were not as significantly associated with POAG in a majority African-descent samples. Here, CDKN2B is linked to open-angle glaucoma.