With this consideration, we have noted the presence of rare variants in other immunodeficiency genes (JAK2, JAK3, IL17RA, IL12RB2, CARD14, and TYK2) in our various patients, which could feasibly contribute to the penetrance and/or differences in the clinical phenotypes of the patients (Table 1). The gene discussed is IL12RB2; the disease is immunodeficiency disease.