As chronic exercise adaptations may result from the constant physiological responses to the acute sessions [16], and an increase in systemic VEGF was reported after 12 weeks of WT in patients with PAD [17], it is possible to hypothesize that WT increases VEGF and miRNA-126 expression, thereby decreasing PI3KR2 and SPRED-1 inhibition of the VEGF-angiogenic pathways (i.e., RAF1-MEK-ERK 1/2 and PI3K-AKT-eNOS) to promote muscle capillarization. This evidence concerns the gene SPRED1 and peripheral arterial disease.