Regarding multiple frenula found in patient 1, who had EVC, to the best of our knowledge, multiple frenula are found only in patients affected with ciliopathies including EVC or EVC2-associated EVC, OFD1-associated orofaciodigital syndrome, GLI3-associated Pallister–Hall syndrome, and CEP120-associated short rib thoracic dysplasia 13 with or without polydactyly, CEP120-associated Joubert syndrome, and WDR35-associated short rib thoracic dysplasia 7 with or without polydactyly [22]. Here, GLI3 is linked to polydactyly.