Here we report three APL cases with various genetic aberrations: cryptic <i>PML::RARA</i> fusion, variant <i>RARA</i> rearrangement, and typical <i>PML::RARA</i> fusion with co-existing <i>FLT3-ITD</i> mutation. The gene discussed is FLT3; the disease is acute promyelocytic leukemia.