We herein researched the related literature in the PubMed database (File S1) and reviewed the correlated processes of ferroptosis in male reproduction, especially the abnormal iron metabolism, regulation of GPX4, and lipid peroxidation; we also detailed the challenges and presented several new ideas in the male reproductive field, which could provide a new target for the treatment of male infertility. This evidence concerns the gene GPX4 and male infertility.