Although the associations of the rs12329760/TMPRSS2 T allele and rs2304256/TYK2 A/A genotype with death by COVID-19 did not reach statistical significance, interaction analysis between the IFIH1, TMPRSS2, and TYK2 polymorphisms showed that the presence of four or more minor alleles was significantly associated with risk of death compared to 3 or fewer minor alleles (OR = 2.622, 95% CI 1.026–6.704, p = 0.044, after adjustment for age and ethnicity; Table 5). The gene discussed is TMPRSS2; the disease is COVID-19.