WEE1 and breast cancer: The DDR network is a highly conserved system in various eukaryotic species, and in plants, a number of proteins such as WEE1 (Wee1-like protein kinase) [19], MRE11 (meiotic recombination 11) [20,21], PARP1 (poly(ADP-ribose) polymerase 1) [22], and BRCA1 (breast cancer susceptibility1) [23] have been shown to play important roles in DDR responses to maintain genome stability.