TPM/TPM1 and its different isoforms are reported to be involved in cell motility [34], muscle contraction [35], myofibril organization, myocardial contraction, cardiac development [36,37], stabilization of stress fibers [38], filament protection [39], formation of filopodia [40], the rescue of transformed cells [41], heart muscle contraction, tissue-specific development [42], hypertrophic cardiomyopathy, regulation of cystic fibrosis transmembrane conductance [43], focal adhesion formation, and lamellipodial persistence [44]. Here, TPM1 is linked to hypertrophic cardiomyopathy.