Autocrine IGF2 induced resistance to taxol in BC cells [127], while in non-small-cell lung cancer cells, CAF-dependent activation of the IGF2-AKT-Sox2-ABCB1 signaling was associated with resistance to doxorubicin, which was reverted by IGF1R blockade [128]. The gene discussed is IGF2; the disease is non-small cell lung carcinoma.