SIRT1 and hepatocellular carcinoma: Resveratrol has also been explored for its role in hepatocellular carcinoma management, and the main effects were observed to be downregulation of Bcl-2, caspase-3 and caspase-7, along with increased phosphorylation of phosphoinositide 3-kinase (PI3K) and serine/threonine-protein kinase (AKT) as well as sirtuin-1 (SIRT-1) activation, which in turn reduces cellular proliferation and migration [32].