This work analyzed the DEGs in the EC of AD by computational bioinformatics approaches, and indicated that AKAIN1 and TRMT2B were up-regulated genes, and SLC22A2, ITGB2-AS1, NIT1, FGF14-AS2, SEMA3E, PYCARD, PRORY, ADIRF were down-regulated genes that might play meaningful roles in AD. The gene discussed is SEMA3E; the disease is Alzheimer disease.