Melanoma CSCs can educate neutrophils to support cancer progression in several ways, such as neutrophil recruitment via TGF-β, IL6, and IL8, enhancing N2-polarization by the activation of ERK, STAT3, and P38 pathways, as well as the overexpression of CXCR2 and NF-kB [97]. The gene discussed is TGFB1; the disease is cancer.