TGFB1 and neoplasm: According to the results from liver, gastric, renal, and thyroid cancers, exosomes derived from CSCs can influence apoptosis, angiogenesis, EMT, and metastasis formation by modulating the expression of p53, Bcl2, VEGF, angiopoietin1, TGFβ, matrix metalloproteinase (MMP)2 and MMP9, as well as by displaying a pro-tumor miRNA profile [99,100,101,102,103].