In addition, granulocyte colony-stimulating factor (G-CSF), C-C motif chemokine ligand (CCL)2, CCL15, and chemokine (C-X-C motif) ligand (CXCL)12 produced by CSCs recruit additional MDSCs to the TME in colon cancers [51,52]. The gene discussed is CSF3; the disease is malignant colon neoplasm.