CAT and lung cancer: In order to test the marker genes of B2-protein-induced stress signals, such as Nrf2, catalase, MnSOD, and Cu/ZnSOD, at the mRNA level, we examined its effect on an A549 lung cancer cell-induced solid tumor grafted on NOD/SCID mice (Figure 4B and Figure 5) using the real-time q-PCR approach.