TP53 and lung cancer: In summary (Figure 8), the mitochondrion-targeting B2 protein induced ROS/p38/Nrf2-mediated oxidative stress and triggered multiple signals, resulting in the induction of both the p53/Bax-apoptotic pathway and the RIPK3-mediated necroptotic pathway to kill A549 lung cancer cells and suppressed tumor marker expression, such as that of CD133, Thy1, and napsin, which regulate cancer cell migration and metastasis.