In summary (Figure 8), the mitochondrion-targeting B2 protein induced ROS/p38/Nrf2-mediated oxidative stress and triggered multiple signals, resulting in the induction of both the p53/Bax-apoptotic pathway and the RIPK3-mediated necroptotic pathway to kill A549 lung cancer cells and suppressed tumor marker expression, such as that of CD133, Thy1, and napsin, which regulate cancer cell migration and metastasis. The gene discussed is PROM1; the disease is neoplasm.