VEGF, an inflammatory cytokine, is the key driver of sprouting angiogenesis and is well-known to be overexpressed in tumor cells, via induction of HIF-1α under hypoxic conditions, promoting proliferation and migration of vascular endothelial cells and blood vessels outgrowth, thereby assisting the growth and metastasis of tumors [10,29]. This evidence concerns the gene VEGFA and neoplasm.