Some authors have hypothesized that apart from the greater release of endothelin-1, lower production of nitric oxide in the arteriole wall as well as microvascular rarefaction (involving the apoptosis of endothelial cells and the remodelling of capillary beds) could also be responsible for VEGF-inhibitor-related hypertension [76,77,78]. This evidence concerns the gene VEGFA and hypertensive disorder.