VEGFA and hypertensive disorder: The results of other studies also demonstrated that TKI-induced hypertension may be associated with greater systemic afterload following VEGF inhibition as well as the destruction of endothelial cells, VEGF-receptor-inhibition-related disturbances in vasoconstrictor–vasodilator balance, lower survival of mesangial cells and impaired glomerular function and filtration [79,80,81,82].