Additionally, the finding of eosinophilia, the increase in TH-2-associated cytokines and chemokines (e.g., TARC and macrophage-derived chemokine (MDC)), and the high proportion of IL-4 and IL-13-producing CD4+ T cells in DiHs/DRESS, suggest that TH2 cells play an essential role in the pathogenesis of DiHS/DRESS [148,151,152,153,154].” Here, CCL22 is linked to Increased total eosinophil count.