Another set of results revealed that an anti-TNFR2 antibody (TY101), in combination with HMGN1 (N1, a dendritic cell stimulating TLR4 agonist) and R848 (a synthetic TLR7/8 agonist) effectively depleted Tregs and boosted cytotoxic CD8 T cells in mouse colon tumors [42]. Here, TNFRSF1B is linked to colonic neoplasm.