Zhao et al. reported that the TNF receptor controls MDSCs development in a cancer cell line, and although malignant rejection was found to be TNF-dependent and was correlated with the proliferation of MDSCs, TNFR2-deficient (TNFR2−/−) animals failed to promote MDSC formation and exhibited decreased cancer progression after malignant tumor implantation [68]. Here, TNFRSF1B is linked to cancer.