These differentiated CD4+ T subsets, characterized by specific transcription factors, exert a broad range of immune responses in TME; TH1 (T-bet), TFH (BCL6), and TH9 cells are associated with antitumor activity, while TH2 (GATA3), TH17 (RORt), Tregg (FOXP3) cells promote tumor growth [68]. Here, CD4 is linked to neoplasm.