CD4 and neoplasm: The tumor microenvironment (TME) is comprised of immune cells (such as TAMs, DCs, MDSCs, Tregs cells, CD8+, CD4+, NK cells), stromal cells (fibroblasts), extracellular matrix (cytokines, chemokines, growth factor), and blood vessels present in the vicinity of cancer cells play a crucial role in cancer progression [25,26].