For example, moesin is regarded as a biomarker of endothelial injury in sepsis, associated with increased vascular permeability [25]; mRNA expression of transgelin in aortic tissue is downregulated in AD patients compared to healthy subjects [26]; and kallistatin, a serine proteinase inhibitor, is negatively associated with the diagnosis and growth of abdominal aortic aneurysms [27]. This evidence concerns the gene SERPINA4 and Alzheimer disease.