The aim of our study was to assess the association between polymorphisms in the TGF-β1 gene (rs1800469, rs1800470) and in the TGFBR2 gene (rs6785358, rs9838682) and the risk of unstable angina, as well as selected clinical parameters affecting the risk of ischemic heart disease. The gene discussed is TGFB1; the disease is angina unstable.