Second, three cluster-grouped genes became significant CRC-associated factors in the presence of certain cluster combinations: TLA/SN set for MMD/LY (M28, M17, M20, and M21), LY/TLA/SN set for STAT2/TRm (M21), and LY/TLA set for GRB2/SN (M28, M20, and M21; Figure 3a). The gene discussed is STAT2; the disease is colorectal carcinoma.