In addition, the 4R-Pal-p53p induced substantial apoptosis in other mutant p53 cancer cell lines such as lung cancer cell line H1229 (p53 R249S), H889 (p53 C242S, data not shown); colon cancer cell line SW48 (p53 R248W); breast cancer cell lines MCF-7 (overexpressed wt p53), Hs578T (V157F); 2 neuroblastoma cell lines SK-N-H and SK-N-AS with overexpressed wt p53, but not in lines with normal levels of WT p53 or in null p53 cell lines. This evidence concerns the gene TP53 and malignant colon neoplasm.