INS and cancer: For SGRQ activity score, 9 out of the 36 pathways identified in the airway overlapped with those in blood (e.g., pathways in cancer and longevity regulating pathway); for SGRQ impact score, 7 out of the 8 pathways identified in the airway epithelium overlapped with those identified in blood (e.g., mTOR signaling pathway and insulin signaling pathway); for SGRQ symptom score, we identified 20 out of 24 pathways in the airway epithelium that overlapped with blood pathways, including platelet activation, pathways in cancer and Wnt signaling pathway.