In the ENGAGE AF-TIMI 48 (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48), 40.2% of the enrolled patients were aged over 75 years old and 17% over 80 years old (8474 and 1440 patients, respectively). The gene discussed is F10; the disease is atrial fibrillation.