Arntl: aryl hydrocarbon receptor nuclear translocator such as FLNA: filamin A, FLNB: filamin B, FTO: fat mass and obesity associated gene, HSD rats: high sodium intake induced hypertensive rats, MC4R: Melanocortin 4 Receptor gene, m6 A-SNP: N6-methyladenosine single nucleotide polymorphism, miR-23a: microRNA-23a, mRNA: messenger ribonucleic acid, mTAL: medullary thick ascending limb, NHE1: sodium hydrogen exchanger 1; nucleotides = A: adenine, C: cytosine, G: guanine, T: thymine. This evidence concerns the gene MC4R and obesity due to melanocortin 4 receptor deficiency.