This study concentrated on the various experimental assay characterization of the antioxidant condition in autism by examining the redox transcription factors NF-κB in this serum at different levels, which increased in NF-κB serum fold 2.38 found in concentration on the ASD cases as differentiated to various mechanisms implication of the activation of NF-κB inflammatory signaling pathway in the etiology of ASD possibility due to the increasing burden of oxidative levels. This evidence concerns the gene NFKB1 and autism.