Among the SNPs associated with NAFLD, one splicing site SNP rs72613567 in hydroxysteroid 17β-dehydrogenase (HSD17B13) gene confers a protective effect on NAFLD risk, particularly lowering the inflammation, NASH, and fibrosis (Figure 1) [150]. The gene discussed is HSD17B13; the disease is metabolic dysfunction-associated steatotic liver disease.