In the Asian populations, a study of Korean NAFLD individuals showed that the PRS model (PNPLA3, TM6SF2, IR, liver enzymes, C-reactive protein, and diabetes status) predicted NASH risk with the area under the curve (AUROC) of 0.835 and 0.809 in NAFLD individuals with and without diabetes, respectively [115]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.