SHANK3 and Anxiety: In addition, DNA methylation and histone modifications regulate gene expression, such as brain-derived neurotrophic factor (BDNF) [5], forkhead box p (Foxp1) [6], SH3 and multiple ankyrin repeat domains 3 (Shank3) [7], autism susceptibility candidate 2 (Auts2) [8], myristoylated alanine-rich C-kinase substrate like 1 (Marcksl1) [9], and function in anxiety-like, autism-like and cognitive phenotypes.