GRIN2B and nervous system disorder: In terms of serine, patients with GRIN2B-related pediatric encephalopathy showed remarkably improved communication, social and cognitive functions when dosed with L-serine for an extended period suggesting that L-serine may enhance glutamatergic neurotransmission and correction of excitatory or inhibitory neurotransmitter imbalance linked to a wide range of neurological disorders [22].