IL1B and Anxiety: Animal and human research show that the relative abundances of the genera Tyzzerella correlates with circulating pro-inflammatory cytokines (IL-1β) and certain behavioral outcomes, such as lethargy and anxiety-like behavior in chemotherapy-induced inflammation in female mice [213], as well as increased abundance by eightfold in neurogenerative diseases, such as in pediatric multiple sclerosis in humans [214].