On the other hand, double deletion on FFAR2 and FFAR3 (whole body or at pancreatic level) leads to greater insulin secretion and improvement of glucose tolerance in obese, T2DM mice fed with high fat diet compared to controls, but with no effect on glucose control if the deletion of the receptors was in the intestinal cells. The gene discussed is FFAR2; the disease is type 2 diabetes mellitus.