INS and type 2 diabetes mellitus: Fasting administration of a solution (containing 20 g of apple cider vinegar, 40 g of water and 1 tsp saccharine) compared to placebo, 2 min before the ingestion of a test meal (containing 87 g of carbohydrates), raised whole-body insulin sensitivity in the first hour of postprandial condition by 34% in insulin-resistant subjects and by 19% in T2DM subjects.