TOP2A and hepatocellular carcinoma: Multivariate regression analysis, in the current study, stated that LN metastasis, LINC01564 and TOP2A were independent predictor for mortality, and in agreement with our results, Meng and his coworkers confirmed that in a multivariate analysis, the TOP2A overexpression was an independent indicator of unfavorable overall survival in HCC after adjusting other prognostic indicators [46].