We assessed the inherited thrombophilia gene polymorphisms, including MTHFR C677T, PAI-1 4G/5G, factor V Leiden G1691A, prothrombin G20210A, antithrombin (T7747C, C10446T, 18390-1 ins CT), and fibrinogen (FGA-α G1233A, FGB-β A9692G, FGG-γ G9135T, FGG-γ G10819A, FGG-γ G12688A), in patients with aPLs from the Chinese Han population; however, we only found mutations in the MTHFR C677T genotype and PAI-1 4G/5G in our aPL(+) patients. Here, MTHFR is linked to Rare hereditary thrombophilia.