Among all the detected inherited thrombophilia gene polymorphisms, including MTHFR C677T, PAI-1 4G/5G, factor V Leiden G1691A, prothrombin G20210A, antithrombin, and the fibrinogen polymorphisms, only the gene mutations in MTHFR C677T and PAI-1 4G/5G were found in the enrolled 67 aPL(+) patients. The gene discussed is MTHFR; the disease is Rare hereditary thrombophilia.