Our study aimed to investigate the prevalence of the following important inherited thrombophilia gene polymorphisms: MTHFR C677T, PAI-1 4G/5G, factor V Leiden G1691A, prothrombin G20210A, antithrombin (T7747C, C10446T, 18390-1 ins CT), and fibrinogen (FGA-α G1233A, FGB-β A9692G, FGG-γ G9135T, FGG-γ G10819A, FGG-γ G12688A), in patients with persistent aPLs from the Chinese Han population. Here, MTHFR is linked to Rare hereditary thrombophilia.