Not only can the preoperative determination of tumor size in conjunction with BRAF V600E mutation analyses via FNAB assist in predicting occult central lymph node metastasis in patients with clinically node-negative (N0) neck, but we can consider the elective dissection of the central neck compartment in high-risk patients with multifocal PTC. The gene discussed is BRAF; the disease is metastatic malignant neoplasm in the lymph nodes.