IL10 and Sepsis: In contrast, the release of anti-inflammatory mediators, such as IL-10, prostaglandins, soluble proteins, IL-1 receptor antagonist (IL-1ra), immunomodulatory hormones, inhibitors of pathogen recognition, and several immune suppressor cells are counteracting against the overwhelming inflammation that can induce sepsis immune exhaustion (the increased susceptibility against secondary infection after sepsis) [3].