EWSR1 and neuroblastoma: In particular, elevated circ-CUX1 promotes aerobic glycolysis, growth, and aggressiveness of NB cells by binding to EWS RNA-binding protein 1 (EWSR1) and facilitating its interaction with the MYC-associated zinc finger protein (MAZ); this results in transactivation and transcriptional alteration of CUX1 [37].