In addition, whereas simvastatin did not affect the expression of HMGCR and HMGCS2 as described in the literature, we could still see a significant upregulation of these genes by treatment with atorvastatin and rosuvastatin, indicating there may be another pathway besides SREPB2 that is responsible for the differential anti-proliferative effects in PCa cells. Here, HMGCR is linked to posterior cortical atrophy.