Multiple logistic regression analysis showed association of urine exosomal TIMP (adjusted odds ratio (aOR): 3.09, 95% confidence interval (CI): 0.99–9.6, p = 0.052), angiopoietin-1 (aOR: 2.24, 95% CI: 0.97–5.15, p = 0.058) with lymph node metastasis. This evidence concerns the gene TIMP1 and metastatic malignant neoplasm in the lymph nodes.