In this study, we report on a proband exhibiting a complex NDD associated with multilocus genomic and genetic variants, namely, a maternally inherited familial translocation [t(17;19)(p13.1;p13.3)mat], a 3.2 Mb dup(2)(q14.3q21.1), and a novel frameshift c.4442del, p.(Gly1481Valfs*21) variant within exon 30 of the CHD4. Here, CHD4 is linked to Neurodevelopmental delay.