Though the contribution of MDK inhibition to the immune-modulating role of IFN-γ could not be evaluated under the in vitro background, we still expect a synergistic effect between IFN-γ and MDK inhibition in immune modulation, as MDK has been recently reported to rewire the tumor microenvironment toward a tolerogenic and immune-resistant state, whereas targeting MDK sensitized tumor cells to immune checkpoint blockade treatment [40]. This evidence concerns the gene MDK and neoplasm.