Though high-dose IFN-γ exerts anti-proliferation function, CCK8 analysis showed that a 48 h treatment with IFN-γ alone caused a only 29.6% inhibition rate at a 5000 ng/mL dose, and only a 34.4% inhibition rate, even at a dose as high as 10,000 ng/mL (Figure 4A); strikingly, combined usage of iMDK at 6.6 nM, a low dose resulting in no obvious cell death when used alone (IC50 = 1238 nm, Figure 4B), led to a robust improvement in IFN-γ anti-tumor activity, causing a 53.9% inhibition rate at only 500 ng/mL IFN-γ and a 58.5% inhibition rate at only 1000 ng/mL IFN-γ (Figure 4C). Here, IFNG is linked to neoplasm.