Irrespective of this, by intersecting the JUNB-dependent gene expression profile and IMAGE-based prediction of direct JUNB targets in MCF10A cells, we delineated a 274-gene set which was controlled by TGFβ1 in JUNB-dependent and independent ways in mammary epithelial cells, lung adenocarcinoma and pancreatic cancer cell lines, and showed correlated expression with TGFβ signaling in breast, lung, colon, and pancreatic cancer transcriptomes. Here, TGFB1 is linked to familial pancreatic carcinoma.