Kazuhiro et al. showed that FBLN5 was directly related to angiogenesis [33], which fully confirmed that the poor prognosis of GC patients caused by FBLN5 overexpression was closely related to hypoxia, angiogenesis, MAPK signaling pathway, EMT signaling pathway, and TGF-β activation, suggesting that FBLN5 could be an important indicator of the poor prognosis of GC. The gene discussed is FBLN5; the disease is gastric cancer.