PTK2 and intrahepatic cholangiocarcinoma: In addition, it was confirmed [32] that LOXL1, the protein interacting with FBLN5, stimulated angiogenesis through the LOXL1-FBLN5/avb3 integrin/FAK-MAPK axis in intrahepatic cholangiocarcinoma, which resulted in favorable conditions for cancer cell metastasis.