ABCB1 and hepatocellular carcinoma: PAK5 conferred HCC with chemoresistance to adriamycin and 5-fluorouracil by phosphorylating β-catenin and promoting its nuclear translocation, leading to the increased transcription of adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1), a gene responsible for multidrug resistance [69].