Wu et al. [41] and Tsai et al. [42] revealed that Lut can effectively inactivate the AKT/mTOR pathway and reverse epithelial–mesenchymal transition (EMT) to suppress breast cancer cell proliferation and metastasis, as well as downregulating Nrf2-mediated expression to enhance chemosensitivity in breast cancer treatment. This evidence concerns the gene AKT1 and breast cancer.