PIK3CA and cancer: Lut combined with AsA treatment downregulated PI3K/AKT signaling (PI3K, AKT and p70S6K), JNK/p38 MAPK signaling and FAK signaling (integrin β1, paxillin and FAK) and upregulated ERK signaling to induce apoptosis and inhibit cancer cell migration, resulting in an anticancer effect on cervical cancer (Figure 10).