PIK3CA and breast cancer: Previous research revealed that the Lut or AsA induced apoptosis through the inactivation of the PI3K/AKT/mTOR/p70S6K pathway in some common cancers, including glioblastoma [68], lung [69], ovarian [19], colon [21] and breast cancers [41,70], which is consistent with our study finding that AsA, Lut and combination treatment inhibited PI3K, p-AKT and p-p70S6K protein expressions in CaSki and HeLa cells (Figure 7).