Lut combined with AsA treatment downregulated PI3K/AKT signaling (PI3K, AKT and p70S6K), JNK/p38 MAPK signaling and FAK signaling (integrin β1, paxillin and FAK) and upregulated ERK signaling to induce apoptosis and inhibit cancer cell migration. This evidence concerns the gene MAPK8 and cancer.