In 2015, Algaba et al. [23] showed that 6 patients had an IBD flare in the follow-up, of those, 4 were not receiving IBD therapy, 1 AZA, and 1 ADA: they required adding thiopurines and/or anti-TNF-α drug treatment (2 ADA, 2 AZA, 1 AZA + IFX, and 1 MTX + ADA). Here, TNF is linked to inflammatory bowel disease.