However, in two studies including index skin cancers alone, the risk of new or recurrent cancers was statistically higher in the group on IMM (71.6 per 1000 p-y) compared to patients without therapy (50.8 per 1000 p-y, p = 0.035) and numerically higher than anti-TNFα (55.5 per 1000 p-y, p = ns). The gene discussed is TNF; the disease is cancer.