SLC9A1 and cancer: This new paradigm of the hydrogen ion dynamics of cancer has recently permitted the integration of many etiopathogenic intermediary factors of different origins and natures causing cancer within a single and wider ranged model based upon cellular alkalization, the upregulation of NHE1 and deranged “mass effect” of the concentration of hydrogen ions (H+) within the intracellular space [29] (Table 2 and Figure 1).