In addition, a tumor-burden mice model by cell transplantation further demonstrated the promotion of tumor growth by pMX-CCAT2 in vivo (Figure 5H,I), which was associated with increased levels of cell proliferation factors (Ki67 and CCND1, Figure 5J) and cell stemness genes (h-TERT, NANOG, SOX2, KLF4 and OCT4, Figure 5K). Here, POU5F1 is linked to neoplasm.