GLS2 and glioma: The overexpression of GLS2 in human glioma cell lines minimizes the malignant phenotype [10], sensitizes cells to oxidative stress by a common mechanism involving the suppression of the PI3K/AKT pathway [13], and induces an antiproliferative response with cell cycle arrest at the G2/M phase and partial translocation of GLS2 proteins to the cell nuclei [14].